Some early notes on using uMatrix to replace NoScript in Firefox 56
(Since I'm also using uBlock Origin, I turned off all of uMatrix's site blocklists as just being duplication.)
(This wide use of scoped permissions does make it harder to get a relatively global overview of what your permissions are. Of course part of this is that you're probably going to have more rules than you would have had in NoScript; I know that I do.)
When I switched over to uMatrix, I ran into my old Twitter no-JS endless redirect problem. In NoScript, this was fixed by a magic option to ignore META redirections in <noscript> elements. uMatrix does not have such a magic option, so I wound up turning off its 'spoof <noscript> tags' setting. This turns out to have useful side effects (for example, it turns out that Stack Overflow's obnoxious red 'we're better with JS' banner is in a <noscript> element). However, some things don't work with this off, such as external links on Tumblr sites. Fortunately uMatrix lets you enable this on a per-site basis.
(I believe that uMatrix also lets you disable <noscript> spoofing on a per-site basis, so in theory I could leave it enabled everywhere and just disable it on Twitter. But since the side effects of disabling it globally seem to be mostly positive, I'm sticking with my default-off for now.)
(So far the most annoying bit of the transition is that my Google search settings got damaged, again. If you do things just right, Google will give you cookies so that you get a nice, functional search experience even without JS and will stick to google.com; however, the settings are quite fragile, fall off easily, and there's no obvious way to fully set yourself back to them.)